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With hypnotic doses, respiratory depression made by barbiturates is similar to that which takes place for the duration of physiologic snooze and is accompanied by a slight reduce in blood pressure and coronary heart fee.Barbiturates are weak acids that happen to be absorbed and rapidly distributed to all tissues and fluids, with higher concentratio
Nonteratogenic Effects. Stories of infants suffering from extended-expression barbiturate publicity in utero integrated the acute withdrawal syndrome of seizures and hyperirritability from start to the delayed onset of as many as 14 days (see DRUG ABUSE AND DEPENDENCE).The poisonous dose of barbiturates differs considerably. Barbiturate intoxicatio